The primary role of platelets in your body is to stop bleeding. Each year in the U.S. alone, over 2 million platelet transfusions are given to treat bleeding complications caused by traumatic injury, surgery and a variety of blood-related ailments.
Problem: Natural platelet transfusion products suffer from:
- limited donor availability
- need for blood typing and matching
- high risk of contamination
- very short shelf life (only 3-5 days)
- minimal portability
- biologic side effects
Solution: SynthoPlate is a synthetic platelet technology that can mimic natural platelet's ability to stop bleeding while having the following properties:
- large-scale manufacture
- no need for typing and matching
- minimal contamination risk due to effective sterilization
- long and convenient storage
- high portability
- absence of biologic side effects
Since significant blood loss is a major cause of death in civilian and military trauma, Haima is focused on developing SynthoPlate for the treatment of traumatic bleeding.
- Intravenous synthetic platelet (SynthoPlate) nanoconstructs reduce bleeding and improve 'golden hour' survival in a porcine model of traumatic arterial hemorrhage. Sci Rep 2018.
- In vitro characterization of SynthoPlate (synthetic platelet) technology and its in vivo evaluation in severely thrombocytopenic mice. J Thromb Haemost 2017.
- Platelet-like nanoparticles: mimicking shape, flexibility, and surface biology of platelets to target vascular injuries. ACS Nano 2014.
- A factor VIII-derived peptide enables von Willebrand factor (VWF)-binding of artificial platelet nanoconstructs without interfering with VWF-adhesion of natural platelets. Nanoscale 2014.
- In vitro and in vivo hemostatic capabilities of a functionally integrated platelet-mimetic liposomal nanoconstruct. Biomaterials 2013.
- Mimicking adhesive functionalities of blood platelets using ligand-decorated liposomes. Bioconj Chem 2012.
- Peptide-decorated liposomes promote arrest and aggregation of activated platelets under flow on vascular injury relevant protein surfaces in vitro. Biomacromolecules 2012.